Faculty

Dr. Feng Li Dr. Feng Li Assistant Professor of Pharmaceutics, Pharmaceutical Sciences Location:Flemmie Kittrell Hall216 Phone:757-727-5585

EDUCATION

Ph.D. the University of Tennessee (2011)

M.Sc. National University of Singapore, Singapore (2006)

B.Pharm. Zhejiang University, China (2002)

POSITIONS and EMPLOYMENT

2011-present               Assistant Professor, Department of Pharmaceutical Sciences, Hampton University, Hampton, VA

2006-2011                   Research Assistant, Department of Pharmaceutical Sciences, The University of Tennessee, Memphis, TN

2004-2006                   Research Assistant, Institute of Bioengineering and Nanotechnology,National University of Singapore, Singapore

AWARDS AND HONORS

2014                            AACP New Investigator Award (2014)

2014                            Theme Issue Editor, Advanced Drug Delivery Reviews

2010                            Chinese Government Scholarship for Outstanding Self-financed Students Studying Abroad

2010                            The University of Tennessee Student Travel Award

2008                            AAPS Biotech Student Travel Award

2004-2006                   National University of Singapore Research Scholarship

2002                            Outstanding Graduate of Zhejiang Province

RESEARCH INTERESTS

(1) Design and synthesis of novel biomaterials for drug delivery; (2) Delivery of small interference (siRNA), oligonucleotides (ODNs), microRNA, and genes for treating various diseases; (3) Develop and evaluation innovative formulation for dental diseases.

RESEARCH SUPPORT

Active

NIH SC3                                                                    Li (PI)                          05/2014-04/2017

Project Title: Polymer-drug Conjugate Micelles for Treating Resistant Prostate Cancers

Role: PI                                   Total Amount: $333,000

Completed

AACP New Investigator Award                                  Li (PI)                          01/2014-12/2014

Project Title: Thermosensitive Hybrid Hydrogel for Delivery of Anti-cariogenic Agents

Role: PI                                   Total Amount: $10,000

Hampton University Faculty Research Grant            Li (PI)                          01/2014-12/2014

Project Title: Polymeric Nanomedicine for Treating Multidrug Resistant Breast Cancers

Role: PI                                   Total Amount: $6,000

RESEARCH ARTICLE

  1. Wang H, Li F*, Du C, Mahato RI, and Huang Y*, (2014) Doxorubicin and Lapatinib Combination Nanomedicine for Treating Resistant Breast Cancers, Mol Pharm. 11(8):2600-11 (* Corresponding Author)
  2. Ramaley CC, Leonard SC, Miller JD, Wilson D, Chang S, Chen Q, Li F, Du C, (2014) in vitro Metabolism of 3, 4-Methylenedioxymethamphetamine in Human Hepatocytes. J Anal Toxicol. 38(5):249-55
  3. Ramaley CC, Li F, Du C (2013) Compatibility of Amiodarone Hydrochloride with Vasopressin During Simulated Y-site Administration. Int J Pharm Compd. 17(5) 436-8
  4. Li F, Danquah M, Saurabh S, Wu H, and Mahato RI (2011) Paclitaxel- and lapatinib-loaded lipopolymer micelles overcome multidrug resistance in prostate cancer Drug Deliv and Transl Res. 1(6): 420-428
  5. Lu W, Li F and Mahato RI (2011) Poly (ethylene glycol)-block-poly (2-methyl-2-benzoxycarbonyl-propylene carbonate) Micelles for Rapamycin Delivery: in vitro Characterization and Biodistribution. J Pharm Sci. 100 (6):2418-29
  6. Wu H, Panakanti R, Li F, Mahato RI (2010) XIAP Gene Expression Protects beta-Cells and Human Islets from Apoptotic Cell Death. Mol Pharm. 7 (5):1655–1666
  7. Li F, Danquah M and Mahato RI (2010) Synthesis and Characterization of Amphiphilic Lipopolymers for Micellar Drug Delivery. Biomacromolecules 11 (10): 2610–2620
  8. Sun X, Li F, Wang Y, Liang W. (2010) Cellular Uptake and Elimination of Lipophilic Drug Delivered by Nanocarriers Pharmazie. 65(10):737-42
  9. Li F, Lu Y, Li W, Miller DD, Mahato RI (2010) Synthesis, Formulation and in vitro Evaluation of a Novel Microtubule Destabilizer, SMART-100. J Control Release. 143 (1): 151–158
  10. Li F and Mahato RI (2009) Bipartite Vectors for co-expression of a Growth Factor cDNA and shRNA against an Apoptotic Gene. J Gene Med. 11 (9): 764-771.
  11. Danquah M, Li F, Duke III C, Miller DD and Mahato RI (2009) Micellar Delivery of Bicalutamide and Embelin for Treating Prostate Cancer. Pharm Res. 26 (9): 2081-92.
  12. Yang N, Ye Z, Li F and Mahato RI (2009) HPMA Polymer-Based Site-Specific Delivery of Oligonucleotides to Hepatic Stellate Cells. Bioconjugate Chem. 20 (2):213-221
  13. Li F, Mahato RI (2008) iNOS Gene Silencing Prevents Inflammatory Cytokine-Induced Beta-Cell Apoptosis. Mol Pharm. 5 (3):407–417
  14. Wang Y, Gao JQ, Li F, R SH, Liang WQ (2006) Tri-block Copolymer Pluronic®F127 Sustains Insulin Release and Reduces Initial Burst of Microspheres---in vitro and in vivo Study Colloid and Polymer Science. 285 (2): 233-238
  15. Wang CY, Li F, Yang Y, Guo HY, Wu CX, Wang S. (2006) Recombinant Baculovirus containing the Diphtheria Toxin A Gene for Malignant Glioma Therapy. Cancer Res. 66 (11):5798-806.
  16. Liu BH, Yang Y, Paton JF, Li F, Boulaire J, Kasparov S, Wang S. (2006) GAL4-NF-kappaB Fusion Protein Augments Ttransgene Expression from Neuronal Promoters in the Rat Brain. Mol Ther. 14 (6):872-82
  17. Ong ST, Li F, Du J, Tan YW, Wang S. (2005) Hybrid Cytomegalovirus Enhancer-H1 Promoter-Based Plasmid and Baculovirus Vectors Mediate Effective RNA Interference. Hum Gene Ther. 16 (12):1404-12.
  18. Zheng CH, Liang WQ, Li F, Zhang YP, Fang WJ. (2005) Optimization and Characterization of Chitosan-Coated Alginate Microcapsules containing Albumin. Pharmazie. 60 (6):434-8
  19. Rao YF, Li F, Liang WQ. (2004) Study on Transdermal Permeation and Skin Accumulation of Finasteride Ethosomes Chin Pharm J. 39 (12) 923-5

BOOK CHAPTER

  1. Liu ZY, Li F*(2013) Induced pluripotent stem cells: basics, and the application in disease model and regenerative medicine. in Danquah M and Mahato RI (eds) Emerging Trends in Cell and Gene Therapy, Springer (*Corresponding Author)
  2. Li F, Mahato RI (2013) Role of Promoters and MicroRNA Backbone for Efficient Gene Silencing. in Cheng K and Mahato RI (eds) Advanced Delivery and Therapeutic Applications of RNAi, John Wiley & Sons, Ltd.

REVIEW PAPER

  • Li F, Mahato RI (2010) RNA Interference for Improving the Outcome of Islet Transplantation. Adv Drug Deliv Rev 63(1-2):47-68
  • Li F* and Mahato RI* (2014) MicroRNA and Drug Resistance in Prostate Cancers. Mol. Pharm. 11(8):2539-52. (* Corresponding Author)

EDITORIALS

  • Li F* and Mahato RI* (2015) miRNAs as targets for cancer treatment: Therapeutics design and delivery. Adv Drug Deliv Rev. 2015 Jan;81:v-vi.

CONFERENCE ABSTRACT

  1. Wang H, Li F, Du C, Huang Y (2013) Combination Nanomedicine for Overcoming Multiple Drug Resistance in Breast Cancer AAPS Annual Meeting (San Antonio, TX, 2013)
  2. Zhang J, Li F (2013) Enhanced Topical Retention of Miconazole with Novel Polymeric Nanocarriers AAPS Annual Meeting (San Antonio, TX, 2013)
  3. Saulsbury MD, Heyliger S, Li F, and Parker-Johnson K. (2013) Knock-down of base excision repair genes increases susceptibility to organophospate pesticide toxicity AACR 104th Annual meeting  (Washington, DC 2013)
  4. Li F, Danquah M, Wu H, and Mahato RI (2011) Paclitaxel and Lapatinib Loaded Lipopolymer Micelles Overcome Multiple Drug Resistance in Prostate Cancers AAPS Annual Meeting (Washington, DC, 2011)
  5. Danquah M, Li F, Duke III CB, Miller DD and Mahato RI (2011) Lactic acid and carbonate-based nanotherapies for treating chemoresistant tumors. AAPS Annual Meeting (Washington, DC, 2011)
  6. Li F, Danquah M and Mahato RI (2011) Micelles-Based Combination Therapy for Treating Refractory Prostate Cancer 15th International Symposium on Recent Advances in Drug Delivery Systems (Salt Lake City, UT, 2011)
  7. Li F, Danquah M and Mahato RI (2010) Amphiphilic Lipopolymer Micelles for Drug Delivery. FIP PSWC /AAPS Annual Meeting (New Orleans, LA, 2010)
  8. Lu W, Li F and Mahato RI (2010) Poly(ethylene glycol)-block-poly(2-methyl-2-benzoxycarbonyl-propylene carbonate) Copolymer for Micellar Delivery of Rapamycin. FIP PSWC /AAPS Annual Meeting (New Orleans, LA, 2010)
  9. Li F, Lu Y, Miller DD and Mahato RI (2009) Galactose-Conjugated Polymeric Micelles for Targeted Drug Delivery. AAPS Annual Meeting (Los Angeles, CA, 2009)
  10. Li F, Cheng G and Mahato RI (2008) MicroRNA-Based shRNA for iNOS Gene Silencing. AAPS Annual Meeting (Atlanta, GA, 2008)
  11. Li F, Panakanti R and Mahato RI (2007) Gene Expression and Silencing for Successful Islet Transplantation. 10th Annual Meeting of the American Society of Gene Therapy (Seattle, WA, 2007)

INVITED PRESENTATIONS

  1. Delivery of microRNA Therapeutics, Wuhan University International Forum for Interdisciplinary Sciences and Engineering  (Wuhan, China, June 2014)
  2. Polymeric Nanomedicine for Cancer Treatment, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences (Shanghai, China, June 2014)
  3. Nanomedicine for cancer treatment. Shanghai Institute of Materia Medica, Chinese Academy of Sciences (Shanghai, China, June 2012)
  4. Paclitaxel and Lapatinib loaded Lipopolymer Micelles for Treating Refractory Prostate Cancer. PharmForum (Memphis, TN, 2011)

TEACHING EXPERIENCE

  • Pharmaceutics PHA361/362 (PharmD course, Hampton University), Role: course coordinator/Instructor
  • Delivery and Biocompatibility of Protein and Nucleic Drugs (Graduate course, the University of Tennessee), Role: Guest lecturer
  • Pharmaceutics Lab (PharmD course, the University of Tennessee), Role: Teaching assistant

SCIENTIFIC REVIEWER FOR JOURNAL

  1. AAPS PharmSciTech
  2. Advanced Drug Delivery Reviews
  3. Bioconjugate Chemistry
  4. Biomacromolecules
  5. Cancer Letters
  6. Chinese Medicine
  7. Critical Reviews in Therapeutic Drug Carrier Systems
  8. Drug Delivery and Translational Research
  9. Drug Development and Industrial Pharmacy
  10. European Journal of Pharmaceutical Sciences  
  11. International Journal of Pharmaceutical Investigation
  12. International Journal of Pharmaceutics
  13. Journal of Biomedical Materials Research: Part A
  14. Journal of Colloid and Interface Science
  15. Journal of Controlled Release
  16. Journal of Drug Targeting
  17. Macromolecular Symposia
  18. Molecular Pharmaceutics
  19. Nanoscale Research Letters
  20. Pharmaceutical Research
  21. PLOS ONE
  22. Scientific Reports
  23. The AAPS Journal

EDITORIAL BOARD

  • International Journal of Pharmaceutical Investigation
  • Journal of Pharmaceutics & Pharmacology
  • Journal of Drug Design and Research

MEMBERSHIP

  • American Association of Colleges of Pharmacy (AACP)
  • American Association of Pharmaceutical Scientists (AAPS)
  • American Association for Cancer Research (AACR)